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1、ARDS病例中氧合指数与SPO2 / FiO2的比较观察卢树标振宇吴碧彤刘涓涓叶文慧 陈晓云李志军黄森权踪李敏雄潘女好李志波付亮摘要目的:探讨急性呼吸窘迫综合征(ARDS)患者的氧合指数与SPO2/FiO2 之间的关系。方法:回顾性采集模型组140例患者及验证组92例患者，对应地采集 SPO2/FiO297%,PEEP5cmH2O)及PaO2/FiO2。两组患者分别采用相关检验中 的 spearman 检验来了解 SPO2/FiO2 与 PaO2/FiO2 的相关性，采用 linear regression 求出其两者的线性方程，然后用受试者工作特征曲线(ROC)检验SPO2/FiO2对 AR
2、DS的诊断效能。结果：在模型组140例病例156对数据中,氧合指数与 SPO2/FiO2 的关系方程为 SPO2/FiO2=73+0.946xOIP V 0.000;r=0.878。当 SPO2/FiO2=262mmHg相当于氧合指数=200mmHg，验证组92例病例118对数据 中氧合指数与SPO2/FiO2亦存在相类似的线性关系，以SPO2/FiO2=262mmHg为 判定阈值时，敏感性为90.12%,特异性为86.49%。使用ROC曲线对SPO2/FiO2对 ARDS的诊断能力进行检验，模型组曲线下面积为0.876，验证组曲线下面积为 0.941。结论:在ARDS患者病情监测中，SPO2
3、/FiO2在一定程度可替代氧合指数。关键词急性呼吸窘迫综合征氧合指数SPO2/FiO2比较AbstractObjective:To investigate the relation between oxygenation index and SPO2/FiO2 in the patients with ARDS.Methods:Corresponding measurements of SPO2 and PaO2 from patients with ARDS trial of a lower tidal volume ventilator strategy(n=140) were compa
4、red to determine the relationship between S/F and P/F.S/F threshold values correlating with P/F ratios of 200(ARDS) were determined. Similar measurements from patients enrolled in the trial of lower positive end-expiratory pressure(n=92) were utilized for validation.Receiver operator characteristic(
5、ROC) curves were plotted to assess the degree of discrimination between S/F and P/F ratios.Results:In the derivation data set(156 measurements)，the relationship between S/F and P/F was described by the following equation:S/F=73+0.946xOIP V 0.000;r=0.878.An S/F ratio of 262 corresponded with a P/F ra
6、tio of 200，The validation database(118 measurements) produced a similar linear relationship.The S/F ratio threshold values of 262 resulted in 90.12% sensitivity with 86.49% specificity for P/F ratios of 200.respectively，AUC for Derivation Data Set and Validation Data Set was(0.876vs0.941).Conclusion:SPO2/FiO2 to a certain extent，can be used as an alternative data for the oxygenation index to diagnose ARDS.
ARDS病例中氧合指数与SPO2／FiO2的比较观察
