AminoAcidsProteinsandEnzymesHartnell氨基酸的蛋白质与酶
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1、1会计学AminoAcidsProteinsandEnzymesHartnell氨基酸的蛋白质与酶氨基酸的蛋白质与酶2 H H Zwitterion (ionized form)3with acidic side chains. basic (hydrophilic) with NH2 side chains.Nonpolar PolarAcidicBasic Copyright 2009 by Pearson Education, Inc.4Copyright 2009 by Pearson Education, Inc.5 Copyright 2009 by Pearson Educati
2、on, Inc.678polar9CH2SHH2NHCOOHCH2SH HNH2 COOHCH3HNH2COOHCH3H2NHCOOH10NH2CH2COHH3NCH2COGlycine Zwitterion of glycine1112131415 Copyright 2009 by Pearson Education, Inc.161718 Copyright 2009 by Pearson Education, Inc.193 +| |H3NCH2CNCHCOpeptide bond20 Copyright 2009 by Pearson Education, Inc.21222324
3、+ H3NCHCNCHCNCHCNCHCO25H3NCHCNCHCNCHCNCHCOAlaLeuCysMet26 Copyright 2009 by Pearson Education, Inc.27AlaLeuCysMetCH3SHCH2CH3SCH2CH2CHOO-CCHHNOCCHHNOCCHHNOCCHH3NCH3CH3CH28 Copyright 2009 by Pearson Education, Inc.2930 a corkscrew shape that looks like a coiled “telephone cord.” Copyright 2009 by Pears
4、on Education, Inc.31323334D. 4 three peptide chains woven like a rope35or more) in grains and vegetables.Essential amino acids 3637383940 Copyright 2009 by Pearson Education, Inc.Myoglobin41same interactions found in tertiary structures. Copyright 2009 by Pearson Education, Inc.424344454647 agitatio
5、n such as whipping that stretches peptide chains until bonds break.48autoclaves. Copyright 2009 by Pearson Education, Inc.495051525354LigasesUse ATP to combine small molecules555657when the reaction is complete.58E + S ES E + P59 Copyright 2009 by Pearson Education, Inc.60 Copyright 2009 by Pearson
6、Education, Inc.6162636465 Copyright 2009 by Pearson Education, Inc.66muscle and liver.67 Copyright 2009 by Pearson Education, Inc.6869as denaturation occurs.70disrupted.7172maximum activity. 73747576concentration.77reversed by adding more substrate. Copyright 2009 by Pearson Education, Inc.787980818
7、2 Copyright 2009 by Pearson Education, Inc.83848586 Copyright 2009 by Pearson Education, Inc.87NNNNHH3CH3CCH2CHCHCHCH2OHOHOHOHOOD-Ribitol 88and whole grains.NCOOH Copyright 2009 by Pearson Education, Inc.89HOCH2CCHCNCH2CH2COHOHOHOCH3CH3 90and nerve damage. Copyright 2009 by Pearson Education, Inc.91
8、broccoli, red and green vegetables.OCHOHCH2OH OHHOO Copyright 2009 by Pearson Education, Inc.92abnormal red blood cells, anemia, and poor growth. Copyright 2009 by Pearson Education, Inc.93H3CCH3CH3CH3CH3CH3CH3H3CCH3H3CCH3CH3CH2OHH3CCH3CH3Beta-caroteneRetinol (vitamin A) Copyright 2009 by Pearson Ed
9、ucation, Inc.94liver oil, egg yolk, and enriched milk. Copyright 2009 by Pearson Education, Inc.95 OCH3HOH3CCH3CH3CH3CH3CH3CH3 963nCH3CH3OOCH3CH3 Vitamin K2 (menaquinone)CH3CH3OOCH3CH3 Vitamin K1 (phylloquinone)97E. Blood clotting98D. 2 VisionE. 3 Blood clotting99100101 + H3NCHCNCHCNCHCNCHCO102 Copyright 2009 by Pearson Education, Inc.103D. 4 three peptide chains woven like a rope104105
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