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1、福建中医药大学文献信息检索综合考试报告（临床各专业）（2012版）选题题目 高度恶性胆道梗阻支架植入术的临床治疗 中英文关键词或主题词10 中文关键词 胆道梗阻 支架植入 治疗 英文关键词 Biliary obstruction sents implantation therpy 研究生姓名 库雷志 学号 2120908001 学科专业 影像医学与核医学 导师姓名 马明平 报告完成日期2012/11/18 总成绩 一、本课题学术论文检索（包括期刊论文、会议论文、学位论文）请按照下列要求逐一回答。50（一）中文医学摘要数据库（中医药在线、CMCC）数据库名称 中医药在线 检索年限 1949年以后

2、 检出篇数 11篇 检索表达式 检索词 胆道梗阻 治疗 列出你认为最相关文献的题名、作者、出处、摘要。1.中文题名中西医结合治疗重症胆道感染80例临床体会著者张东第一著者单位靖江市中医院外科 214500第一著者地址江苏刊名深圳中西医结合杂志年份2001卷11期4页码226-227主题词胆道疾病/中西医结合疗法中文摘要目的：观察中西医结合治疗重症胆道感染的临床疗效。方法：本病特点为肝胆湿热为主，本组用柴胡、黄芩、双花、连翘、金钱草、枳壳、郁金、木香、大黄（后下）、风化硝，随症加减。针刺取日月、期门及胆俞；伴有严重休克配涌泉穴（双）。中转手术组：经中西医结合治疗后症状不能控制或症状缓解，感染得到

3、控制，但胆道梗阻不能解除，择期手术28例。结果：本组80例，治愈72例，总治愈率90%，死亡8例。结论：本法疗效满意。2.中文题名血塞通注射液对梗阻性黄疸肾损伤的保护机制著者宋少莉, 周斌, 程彦斌, 王宏亮, 汤晓琴第一著者单位甘肃 兰州医学院第一医院核医学科 730000第一著者地址甘肃刊名第四军医大学学报年份2004卷25期15页码1368-1371主题词血塞通注射液/药理学；黄疸/病因学；黄疸/并发症；胆汁郁积/并发症；基因，BCL-2/药物作用中文摘要目的:观察血塞通注射液对梗阻性黄疸引起的肾损伤的保护作用。方法:健康日本大耳白兔48只,随机分为2组: A组为胆总管结扎组24只(ob

4、structive jaundice,OJ);B组为胆总管结扎+血塞通注射液组24只。每组又进一步分为4个亚组。建立胆道梗阻动物模型后,在术后不同时期取材测定血清总胆红素(T-BIL)、血肌苷(Cr)和尿素氮(BUN)值;用免疫组化法检测肾组织Bax、Bcl-2的表达情况。结果:胆道梗阻后A、B两组的肾脏均有Bcl-2和Bax蛋白表达,Bax蛋白在梗阻9 d时达高峰。Bcl-2蛋白在梗阻21 d达高峰.凋亡指数(AI)随Bax的升高而升高,随Bcl-2的升高而降低。B组Bax蛋白表达较同时相组弱,而Bcl-2蛋白表达较同时相组强。B组AI值较A组降低。结论:血塞通注射液对梗阻性黄疸肾损伤有保护

5、作用,其机制可能是通过上调肾组织Bcl-2蛋白表达,下调肾组织Bax蛋白的表达来实现的。3 中文题名黄芪对梗阻性黄疸大鼠肝功能的保护作用著者鲍鹰, 冯文明, 费卯云, 陈秋强, 杨琦, 戴闯第一著者单位浙江 湖州市第一医院肝胆外科研究所 313000第一著者地址浙江刊名中国中西医结合外科杂志年份2004卷10期4页码278-280主题词胆汁郁积/并发症；胆汁郁积/病理生理学；胆汁郁积/中医药疗法；黄芪注射液/药理学；黄芪注射液/投药和剂量；注射，腹腔内；内皮素1/血液；超氧化物歧化酶/血液；丙二醛/血液；天冬氨酸氨基转移酶类/血液；胆红素/血液；胆汁酸类和盐类/血液；黄疸，阻塞性/中医药疗法；

6、黄疸，阻塞性/病因学中文摘要目的:探讨黄芪注射液对实验性梗阻性黄疸大鼠肝功能的保护作用及作用机理。方法:SD大鼠行胆总管结扎后分别用3 mL黄芪注射液或生理盐水腹腔注射。术后测定血浆内皮素(ET-1)、血清超氧化物歧化酶(SOD)、丙二醛(MDA)含量,同时测定谷丙转氨酶(AST)、直接胆红素(DB)和总胆汁酸(TBA)浓度,并对肝脏行光镜下病理形态学观察。结果:血浆ET-1、血清MDA浓度在梗阻10 d即升高,随胆道梗阻时间延长进一步升高,SOD在梗阻10 d即下降,同时伴有血清AST、DB和TBA的升高和肝脏病理形态学的进行性改变。黄芪治疗组ET-1及MDA显著低于对照组,而SOD显著高于

7、对照组,并能改善肝组织病理形态。结论:大鼠梗阻性黄疸时,血浆ET-1水平升高及氧自由基损害可能是肝损伤的原因,黄芪通过降低ET-1水平、抗氧化作用对梗阻性黄疸大鼠的肝脏起保护作用。4 中文题名黄芪对胆道梗阻后心肌损伤保护作用的实验研究个人著者巩鹏; 王忠裕; 李克军;第一著者单位大连医科大学第一临床学院 116011第一著者地址辽宁刊名中国中西医结合外科杂志年份2000卷6期6页码409-411中文文摘 目的:观察胆道梗阻后心肌损伤及黄芪(AM)的保护作用。方法 :动态观测心肌组织丙二醛(MDA)和超氧化物歧化酶(SOD)、血清T-Bil、 TBA、内毒素(ET)、肿瘤坏死因子(TNF)含量;

8、取左室心肌行光电镜检查,应用A BC免疫组化染色法,定位TNF在心肌组织中的表达和分布。结果:胆道梗阻后,血清T-Bil、TBA、ET、TNF水平逐渐升高,心肌组织MDA含量逐渐升高,SOD逐渐减少;各AM治疗组与同时相梗阻组比较,血清 ET、TNF、心肌组织MDA含量减少,SOD含量升高;心肌组织MDA含量与血清TNF含量变化呈正相关;光电镜下可见随胆道梗阻时间延长,心肌组织细胞损害加重,各AM治疗组与同时相梗阻组比较组织细胞损害减轻。结论:AM通过对抗自由基损伤、内毒素血症、TNF的综合作用,对胆道梗阻所致心肌损伤有明显保护作用。5中文题名丹参注射液对梗阻性黄疸大鼠肝内NO、MDA、ET的

9、影响及其意义个人著者李小刚; 刘青光; 潘承恩; 马清涌; 张梅第一著者单位西安交通大学第一医院麻醉科 710061第一著者地址陕西刊名西安医科大学学报年份2002卷23期2页码158-161中文文摘目的:探讨丹参注射液对梗阻性黄疸(Obstructive jaundice,OJ)大鼠肝组织中一氧化氮(NO)、丙二醛(MDA)、内皮素(ET)的影响及其意义。方法:采用双重结扎切断大鼠胆总管造成OJ模型,分别给大鼠腹腔注射生理盐水(模型组)和丹参注射液(治疗组), 各组于术后7d和14d观察肝组织匀浆NO2-+NO 3-、MDA、ET含量,肝功能及肝组织形态改变。结果:胆道梗阻7d和14d后大鼠

10、肝组织中NO2-+NO3-、MDA含量较正常鼠明显增加,两者不随梗阻时间延长而升高;肝组织中ET含量亦明显增高,且随时间延长而增高。丹参治疗组大鼠肝组织中NO2-+NO3-与模型组无差异,而MDA和ET含量明显低于模型组,血浆ALT、AST明显降低,肝组织损伤减轻。结论:丹参注射液可降低 OJ大鼠肝内MDA、ET含量,从而发挥肝脏保护作用。数据库名称 CMCC 检索年限 2007-2012 检出篇数 15篇 检索表达式 检索条件：胆道梗阻/FLD=关键词,题名,外文题名,摘要 AND 支架植入/FLD=关键词,题名,外文题名,摘要 AND #年=2007 AND #年 0.05). CONCL

11、USION. Our study data showed that stent placement across the main duodenal papilla seemed to prevent early infectious complications after percutaneous metallic .3、你能否获取该数据库命中文献中的一篇全文？请拷贝粘贴全文的PDF首页。答；能数据库名称 FMJS 检索年限 2007-2012 ；检出文献题录数 94篇 中英文检索词 胆道梗阻支架植入 Biliary obstruction stents implantation 检索表达式

12、 自由词全部=Biliary obstruction stents implantation 1、列出你认为最相关的篇文献的题录，并复制粘贴该篇文献标引的全部主题词。1题名：Biliary stents.作者：Meyenberger Ch;Fantin AC ;出处：Ther Umsch.2003V60N4:225-32文献类型：Comparative Study;English Abstract;Journal Article;Review;ISSN：0040-5930 (Print)0040-5930 (Linking)语种：ger出版国：Switzerland摘要：PURPOSE: Re

13、trospective analysis of our results with metallic stent placement for malignant biliary strictures. We sought to determine parameters that influence stent patency. METHODS: A total of 95 Wallstents were implanted in 65 patients (38 men, 27 women; mean age, 65.1 years) with malignant biliary obstruct

14、ion. Serum bilirubin levels were assessed in 48 patients; the mean value prior to intervention was 15.0 mg/dl. RESULTS: In 12 patients (21%) complications occurred as a result of percutaneous transhepatic drainage. Stent implantation was complicated in 13 patients, but was possible in all patients.

15、A significant decrease in bilirubin level was seen in 83.3% of patients following stent implantation. Approximately 30% of patients developed recurrent jaundice after a mean 97.1 days. In 9 patients (15%) the recurrent jaundice was caused by stent occlusion due to tumor growth. The mean follow-up wa

16、s 141.8 days, the mean survival 118.7 days. Patients with cholangiocarcinomas and gallbladder carcinomas had the best results. Worse results were seen in patients with pancreatic tumors and with lymph node metastases of colon and gastric cancers. CONCLUSIONS: The main predictive factors for occlusio

17、n rate and survival are the type of primary tumor, tumor stage, the decrease in bilirubin level, and the general condition of the patient.主题词MeSHBile Duct Neoplasms/complications 【胆管肿瘤/并发症】*Bile Ducts 【胆管】Bile Ducts, Intrahepatic 【胆管, 肝内】Cholangiocarcinoma/complications 【胆管上皮癌/并发症】Cholangitis, Scler

18、osing/complications 【胆管炎, 硬化性/并发症】Cholecystectomy/adverse effects 【胆囊切除术/副作用】Cholelithiasis/complications 【胆结石/并发症】Cholestasis/etiology/surgery/*therapy 【胆汁淤积/病因学/外科学/治疗】Common Bile Duct 【胆总管】Constriction, Pathologic/etiology/therapy 【缩窄, 病理性/病因学/治疗】Endoscopy 【内窥镜检查】Humans 【人类】Liver Neoplasms/compli

19、cations/secondary 【肝肿瘤/并发症/继发性】Liver Transplantation/adverse effects 【肝移植/副作用】Lymphatic Metastasis 【淋巴转移】Metals 【金属】*Pancreatic Ducts 【胰腺管】Pancreatic Neoplasms/therapy 【胰腺肿瘤/治疗】2题名：Biliary stents.作者：Meyenberger Ch;Fantin AC ;出处：Ther Umsch.2003V60N4:225-32文献类型：Comparative Study;English Abstract;Journ

20、al Article;Review;ISSN：0040-5930 (Print)0040-5930 (Linking)语种：ger出版国：Switzerland摘要：Endoscopically implantable stents are today the mainstay for therapy of biliary stenoses. It is important to know if a benign or a malignant stenosis is the cause of the biliary obstruction. Generally benign stenoses

21、are treated with plastic-stents whereas malignant stenoses are managed by implantation of a metallic stent. The main indications for plastic stents are postoperative strictures in the biliary tree for example, after biliary tract surgery or liver transplantation, primary sclerosing cholangitis and p

22、ostoperative biliary leakage. Metallic stents are implanted in palliative circumstances like in stenosing cholangiocarcinoma or in situations where a hepatic metastasis exerts an extrinsic compression on the biliary tract with consecutive cholestasis. The materials used for manufacturing both stent

23、types are biologically inert and thus biocompatible. A current poorly resolved problem is the occlusion of the stent lumen (by sludge, bacterial degradation products etc.) which occurs in both stent types with time. These problems lead to stentocclusion around three to six months after implantation

24、and necessitate endoscopical re-interventions in order to overcome the occlusion. The patency rate for metallic stents is better than for plastic ones. The endoscopic stenttherapy is equivalent to surgical therapy (Intestinal bypass-procedures.主题词MeSHBile Duct Neoplasms/*complications 【胆管肿瘤/并发症】Chol

25、angiocarcinoma/*complications 【胆管上皮癌/并发症】Cholangiopancreatography, Endoscopic Retrograde/adverse effects 【胰胆管造影术, 内窥镜逆行/副作用】Cholangiopancreatography, Magnetic Resonance 【胰胆管造影术, 磁共振】Cholestasis/*etiology/surgery/*therapy 【胆汁淤积/病因学/外科学/治疗】Constriction, Pathologic/etiology/therapy 【缩窄, 病理性/病因学/治疗】Huma

26、ns 【人类】Jaundice, Obstructive/etiology/surgery/*therapy 【黄疸, 阻塞性/病因学/外科学/治疗】Metals 【金属】*Stents/adverse effects 【支架/副作用】2、这2篇文献是否有可扩展或链接的信息？请截图，并简述信息的内容。答；有1.相关链接：Google 引文 PubMed相关文献 Expandable metal stents for malignant hilar biliary obstructionMost patients with malignant hilar stenoses are candida

27、tes for palliation. For this purpose, biliary drainage plays a major role in improving liver function and managing or avoiding cholangitis. Endoscopic interventions are less invasive than the percutaneous approach .网页快照Expandable metal stents for endoscopic bilateral stent-within-stent placement for

28、 malignant hilar biliary obstructionP Chahal, TH Baron - Gastrointestinal endoscopy, 2010 - ElsevierBACKGROUND: Placement of biliary stents is effective for palliation of unresectable hilar malignant biliary obstruction. However, when bilateral self-expandable metal stents (SEMSs) are used, placemen

29、t can be technically challenging. In many studies, side-by- .2相关链接：Google 引文 PubMed相关文献 通道揭示：馆际互借通道 PubMed 电子资源通道揭示 国内馆藏资源通道揭示全文通道：Elsevier Science | EBSCO | OhioLINK Electronic Journal Center | 纸刊Percutaneous placement of metallic stents in the management of malignant biliary obstruction.YY Chiou,

30、HS Tseng, JH Chiang, JI Hwang - Journal of the . Percutaneous placement of metallic stents in the managementof malignant biliary obstruction.网页快照3、你能否获取该数据库命中文献中的一篇全文？请拷贝粘贴全文的PDF首页。答 能数据库名称 ScienceDirect 检索年限 2007-2012 ；检出文献题录数 264篇 中英文检索词 胆道梗阻支架植入 Biliary obstruction sents implantation 检索表达式 pub-da

31、te 2006 and (.Biliary obstruction) and (stents implantation )All Sources(Medicine and Dentistry) 1、列出你认为最相关的篇文献的题录，并复制粘贴该篇文献标引的全部主题词。1. Christian Gerges, Brigitte Schumacher, Grischa Terheggen, Horst Neuhaus, Expandable Metal Stents for Malignant Hilar Biliary Obstruction, Gastrointestinal Endoscopy

32、 Clinics of North America, Volume 21, Issue 3, July 2011, Pages 481-497, ISSN 1052-5157, 10.1016/j.giec.2011.04.004.2. Hai-Dong Zhu, Jin-He Guo, Guang-Yu Zhu, Shi-Cheng He, Wen Fang, Gang Deng, Yong-Lin Qin, Guo-Zhao Li, Douglas M. Coldwell, Gao-Jun Teng, A novel biliary stent loaded with 125I seeds in patients with malignant biliary obstruction: Preliminary results versus a conventional bilia