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1、抗磷脂综合征最新诊断标准临床标准1 .血管栓塞：至少有一次经影像学、超声多普勒或组织学证实的任何脏器或器官的动 脉、静脉或小血管血栓形成发作2 .怀孕异常(1)至少1次不能解释的孕10周或10周以上的胎儿死亡，或(2)至少1次因先兆子痫、子痫或严重胎盘功能不全导致孕34周或34周以上的早产(新生儿形态正常)，或(3)3次或3次以上的孕10周前自发流产实验室标准1 .抗心磷脂抗体：2次中高滴度的IgG或/和IgM型抗体阳性(间隔至少 12周)2 .狼疮抗凝物：2次阳性(间隔至少12周)3 .抗3 2GPI抗体：2次高滴度IgM或IgG型抗体阳性(间隔至少 12周)4 少1条临床标准和至少1条实验
2、室标准即可确诊附原文：Diagnostic Criteria for APSClinical criteria1. Vascular thrombosis : At least one episode of arterial, venous, or small-vesselthrombosis in any tissue or organ confirmed by imaging, Doppler ultrasound, or histopathology2. Pregnancy morbidity(1)At least one unexplained fetal death at or be
3、yond 10 wk, or(2)At least one premature birth of morphologically normal neonate at or beyond 34 wk dueto preeclampsia, eclampsia, or severe placental insufficiency, or(3)Three or more spontaneous pregnancy losses before 10 wk of gestationLaboratory criteria1 .Anticardiolipin antibodies: medium- or h
4、igh-titer IgG and/or IgM on two occasions atleast 12 wk apart2 .Lupus anticoagulant: on two occasions at least 12 wk apart3 .Detection of anti- 3 2GPI antibodies: high -titer IgM or IgG on two occasions at least 12 wk apart* Definite APS is confirmed when at least one clinical criterion and at least onelaboratory criterion are present.摘自：Lockshin MS, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome. JThromb Haemost,2006,4:295-306.
抗磷脂综合征最新诊断标准
