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1、 menwomenEffect of Prior Vertebral Fracture on Risk of Subsequent Vertebral FractureAdapted from Lindsay R et al. JAMA 2001;285:320-23051015Incidence of New VertebralFracture (%)No. of Vertebral Fractures at BaselineRR=7.3 (4.4, 12.3)RR=5.1 (3.1, 8.4)RR=2.6 (1.4, 4.9)First Year of Study011263%16%lIs
2、 fracture healing affected by bisphosphonates?手术后被随机分组手术后被随机分组预选预选417人人钙钙-维生素维生素D3(500 MG/D +400 IU/DAYn=125阿仑膦酸钠阿仑膦酸钠 (70 MG/W) +钙钙-维生素维生素D3(500 MG/D + 400 IU/D)n=114治疗均在患者能够保持治疗均在患者能够保持直立坐位或立位后立即直立坐位或立位后立即开始开始通常为术后通常为术后2至至4 天且均在出院前天且均在出院前主要终点事件：全髋骨密度变化主要终点事件：全髋骨密度变化Adapted from Cecilia et al.Osteo
3、poros Int (2009) 20:903-9101086420-2-4-6 TH TC IT FN LSChange in BMD (%; 95% CI)Patients treated with alendronate+calcium+vitamin D3 vs. patients treated with calcium +vitamin D3. Bone mineral density (BMD; g/cm2) TH:totalhip, TC:trochanteric, IT:inter-trochanteric, FN:femoral neck, LS:lumbar spineAdapted from Cecilia et al.Osteoporos Int (2009) 20:903-910P0.0005Thank you!
骨质疏松治疗方案的应用评价课件
