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1、1会计学TLR激动剂激动剂imiquimod的研究进展的研究进展 resiquimod (S-28463), imiquimod (S-26308). Human peripheral blood mononuclear cells (PBMC)Mo-DC, dendritic cells (DC) derived from monocytes, plasmacytoid dendritic cells (pDC)Imiquimods proapoptotic effect in vitro Imiquimod inhibits cell proliferation in prostate c
2、ancer cell lines.（detected by MTT）Imiquimod induces apoptosis by imiquimod dose-dependent and by pass of mitochondria-dependent in prostate cancer cellsResults: Imiquimod induced apoptosis was independently of TLR7 and MyD88macrophages (M), bone marrow-derived macrophages (BMM) from WT,TLR7+ and TLR
3、7- mice, and mouse aortic SMCs from WT mice.b, e Macrophages and SMCs were incubated for 24 h with imiquimod (0.130 lg/ml). Cell viability was examined by neutralred assays.a Transmission electron-microscopic images of macrophages showautophagosome formation after imiquimod treatment for 7days. b Im
4、ages of SMCs shown autophagosome formation after imiquimod treatmentI, intima; M, media; a, VCAM-1; b, T cells; c, macrophagesb, e Macrophages and SMCs were incubated for 24 h with imiquimod (0.130 lg/ml). Cell viability was examined by neutralred assays.a Transmission electron-microscopic images of macrophages showautophagosome formation after imiquimod treatment for 7days. b Images of SMCs shown autophagosome formation after imiquimod treatment
TLR激动剂imiquimod的研究进展
