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1、2007-2008年第二学期生物化学考试试卷 A答案一、名词解释 （每题4分，共20分）1protein spatial structure is especially sensitive to denaturing agents (high T, urea, strong acids or bases, organic solvents, detergents, heavy metal ions) , result in unfolding and disorganization of protein spatial structure without change in primary s
2、tructure, loss of biological activity. 2Be synthesized and secreted as large inactive precursors called zymogens. activated by the irreversible hydrolysis one or more peptide bonds and forming or exposing the active site in the enzyme molecule. 3. Inside of the mitochondrion; fatty acyl-CoAs are oxi
3、dized in a series of cycles that each cycle release a two-carbon fragment, in the form of acetyl-CoA; Each cycle involves four reactions-dehydrogenation, hydration, dehydrogenation, and thiolytic cleavage.4.To transport ammonia in the nontoxic forms of alanine from muscles to liver. 5In the mitochon
4、drion, The process of the enzymatic phosphorylation of ADP to ATP coupled to electron transfer from a substrate to molecular oxygen is termed Oxidative phosporylation. 二、选择题（每题1分，共40分）A型题1. E 2. B 3. E 4. C 5. D 6. E 7. C 8. B 9. A 10. B 11. C 12. D 13. C 14. A 15. D 16. A 17. C 18. C 19. E 20. AX型题
5、21. ACD 22. ABCD 23. BDE 24. ABCD 25. ACD 26. ADE 27. BCE 28. BCDE 29. ABCE 30. ACD 31. ABCD 32. ACDE 33. BCD 34. ABCDE 35. ABCD 36. ABC 37. AB 38. A 39. BDE 40. ACD三、问答题（每题8分，共40分）1. 谷氨酸脱氢氨酮戊二酸（1）；酮戊二酸天冬氨酸出线粒体草酰乙酸PEP，1）异生，葡萄糖。（3）2）丙酮酸乙酰CoATAC氧化。（2）3）脱下氢，呼吸链，H2O， ATP。（2）2单核-吞嗜细胞：衰老红细胞血红素胆绿素胆红素；（1）血，
6、清蛋白结合运输；（1）肝摄取，配体蛋白转运，结合GA胆红素，胆道入肠；（3）去结合，还原胆素原，肠肝循环尿胆色素，氧化胆素。（3）3合成：GG1PUDPG糖原合酶，引物，糖原。（2）分解：糖原磷酸化酶，G1PG6PG6P 酶，G。（2）调节：激素cAMPPKA 1)磷酸化酶b激酶磷酸化酶糖原分解。（2）2）糖原合酶p化糖原合成。3）磷蛋白磷酸酶抑制物，p化磷酸酶关键酶脱p（2）4合成：肝脏，脂酸氧化乙酰CoA合成HMG CoA裂解乙酰乙酸羟丁酸，丙酮。（3）分解：肝外组织，羟丁酸乙酰乙酸2酶，乙酰乙酰CoA乙酰CoATAC，OXP。（3）肝加工脂酸，输出能源形式。酮体易运输、氧化，饥饿大脑利用供能，重要。（2）5氨主要在肝合成尿素解毒，（2）使生成、分解平衡。肝损伤合成尿素血氨。（2）大脑，氨GluGln，消耗酮戊二酸TAC、ATP 肝性昏迷。（2）降低血氨：减少来源：限制蛋白摄入，治疗内出血；抑制肠菌，酸性液肠透析；不用碱性利尿剂；增加出路，保肝，服Glu，Asp促尿素合成。（2）2
2008七年制生化A答案
