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1、NormalPolycystic liver and kidneyJoseph Murray(USA)Kidney transplantation between identical twins,in 1954Cadaveric kidney transplantation,in 1962Nobel Prize winner in 1990 1978 Cyclosporine Survival 40-50%80-90%Milestones in Organ transplantationFundamentcyclosporineDevelopmentKey pointUnder low T c
2、ondition According to the genetic differencegenetically identical from one species to anotherIn situ lateral partial liver transplantationHost against invaderCsATacOKT3细胞毒细胞毒T T淋巴细胞相关淋巴细胞相关抗原抗原4 4融合蛋白融合蛋白(CTLA4-Ig)CTLA4-Ig)抗抗CD154CD154单抗单抗抗抗CD25CD25单抗单抗SirolimusEverolimus酪氨酸激酶酪氨酸激酶3 3（JAK3JAK3）抑制剂）抑
3、制剂MPAFK778抗抗CD52CD52单抗单抗FTY720AzaOccurs on day 3-5 post-transplantationIg G Ab against endothelial antigen and activation of complement T-cell also contribute to the accelerated rejectionLysis of the endothelial cells and infiltration of inflammatory cellsClinical symptoms and signs:anemia,edema,hyp
4、ourocrinia and transplanted kidney dysfunction Laboratory testing+Tissue biopsyThe presence of T-cells infiltrating the transplanted tissueEvidence of structural injury to the transplanted tissueInjury to the blood vessels in the transplanted tissuenA term used to describe a long-term loss of functi
5、on in A term used to describe a long-term loss of function in transplanted organs.transplanted organs.nThe mechanism of CR is less clearly defined.The mechanism of CR is less clearly defined.nProliferation of endothelial cells and smooth muscle cells,Proliferation of endothelial cells and smooth muscle cells,thereby leading to luminal occlusionthereby leading to luminal occlusionABO blood typingPre-existing Ab detectionHLA typingHLA-A,HLA-B,HLA-DRlymphocytotoxicity testPanel reactivity antibody(PRA)Organ Transplantation我怎能在别人的苦难面前转过身去。我怎能在别人的苦难面前转过身去。切 格瓦拉
外科学：14-Organ Transplantation
