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1、附表 1】附表为常见的糖脂代谢通路主要蛋白，供参考。糖代谢通路主要蛋白检测序 号蛋白名缩写蛋白名全称生物过程1InsInsulin胰岛素信 号通路2IRInsulin receptor3p-IR (Tyr1150/1151)Phospho-insulin receptor (Tyr1150/1151)4p-IR (Tyr 1146)Phospho-insulin receptor (Tyr 1146)5IGF1R (IR)Insulin-like growth factor 16CREBcAMP response element-binding7p-CREB(Ser 133)Phospho-c
2、AMP response element-binding (Ser 133)8C/EBPa p42CCAAT-enhancer-binding proteins p429p-C/EBPa p42Phospho- CCAAT-enhancer-binding proteins p4210p-p38 MAPKPhospho-p38 mitogen-activated protein kinase11p44/42 MAPKp44/42 mitogen-activated protein kinase12p_p44/42 MAPK(Thr202/Tyr204)Phospho-p44/42 mitoge
3、n-activated protein kinase (Thr202/Tyr204)13p70s6kp70S6 kinasep-p70s6k (Thr421/Ser424)Phospho-p70S6 kinase14Aktserine/threonine protein kinase15p- Akt (Ser473)Phospho-serine/threonine protein kinase (Ser473)16p- Akt (Ser308)Phospho-serine/threonine protein kinase (Ser308)1718IRSInsulin receptor subs
4、trate19p-IRSPhospho- insulin receptor substrate20p-IRS (Ser 307)Phospho- insulin receptor substrate (Ser 307)21Ptenphosphatase and tensin homolog22Socs1suppressor of cytokine signaling proteins 123Socs3suppressor of cytokine signaling proteins 324PGC-laperoxisome proliferator-activatedreceptor-丫coac
5、tivator-la25pparyperoxisome proliferator activated receptor gamma26PTP-1BProtein tyrosine phosphatase-1B27UCP1uncoupling protein 128UCP2uncoupling protein 229AMPKAMP-activated protein kinase30p-AMPKPhospho- AMP-activated protein kinase31ACCAcetyl-coA carboxylase32p- ACCPhospho-Acetyl-coA carboxylase
6、333435GSK3卩glycogen synthase kinase 3 beta36P-GSK3卩(Ser9)Phospho-glycogen synthase kinase 3 beta (Ser9)37P-GSK3卩Phospho-glycogen synthase kinase 3 beta38Pdx-1Pancreatic and duodenal homeobox 139PI3KPhosphatidylinositol 3-kinases40Sir2silent information regulator 241SIRT1silent mating type informatio
7、n regulation 2 homolog 142p-p90rsk(ser380)Phospho-p90 ribosomal S6 kinase (ser380)43Pax-6Paired box gene 644Histone4(Ac16)Histone 4 (Ac16)45GlycogenGlycogen其它46TubulinTubulin47ActinActin48Glut4Glucose transporter type 4脂代谢通路主要蛋白检测序 号蛋白名缩写蛋白名全称生物过程1Aacsacetoacetyl-CoA synthetase2Aasdhaminoadipate-sem
8、ialdehyde dehydrogenase3Acaa1aacetyl-Coenzyme A acyltransferase 1A4Acaa2acetyl-CoenzymeAacyltransferase2(mitochondrial 3-oxoacyl-Coenzyme A thiolase)5Acox1acyl-Coenzyme A oxidase 1, palmitoyl6Acoxlacyl-Coenzyme A oxidase-like7Adipor1adiponectin receptor 18Adipor2adiponectin receptor 29Apoa2apolipopr
9、otein A-II10Cpt1acarnitine palmitoyltransferase 1a, liver脂肪酸代11Cpt1bcarnitine palmitoyltransferase 1b, muscle谢过程12Cyb5cytochrome b-513Ehhadhenoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase14Faahfatty acid amide hydrolase15Fabp2fatty acid binding protein 2, intestinal16Hpgdhydroxypr
10、ostaglandin dehydrogenase 15 (NAD)17Hsd17b4hydroxysteroid (17-beta) dehydrogenase 418Lipalysosomal acid lipase A19Lipclipase, hepatic20Pparaperoxisome proliferator activated receptor alpha21Ucp3uncoupling protein 3 (mitochondrial, protoncarrier)22Acaa2acetyl-CoenzymeAacyltransferase2(mitochondrial 3
11、-oxoacyl-Coenzyme A thiolase)脂肪酸B 氧化过程23Adipoqadiponectin, C1Q and collagen domain containing24Ppardperoxisome proliferator activator receptor delta25Apoalapolipoprotein A-I胆固醇合成过程26Fdftlfarnesyl diphosphate farnesyl transferase 127Fdpsfarnesyl diphosphate synthetase28Pmvkphosphomevalonate kinase29A
12、cbd3acyl-Coenzyme A binding domain containing 3类固醇合成30Cyp51cytochrome P450, family 5131Hint2histidine triad nucleotide binding protein 232Lsslanosterol synthase33Pbx1pre B-cell leukemia transcription factor 1胆固醇代 谢过程34Pmvkphosphomevalonate kinase35Srd5a1steroid 5 alpha-reductase 136Srd5a2steroid 5 alpha-reductase 237Tspotranslocator protein38Srebf2sterol regulatory element binding factor 2
sa附表为常见的糖脂代谢通路主要蛋白供参考
