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1、 文献评价报告学生姓名：* 班级: * 学号：* 本科专业：* 现攻读专业：*导师： * 评价论文题目：Association between low-dose folic acid supplementation and blood lipids concentrations in male and female subjects with atherosclerosis risk factors.出处： Med Sci Monit. 2013; 19: 733739.设计类型: DRUG CONTROLLED STUDIES药物对照研究 论文性质：预防1.选题是否具有科学性与创新性?文章的
2、提出有科学性，有创新性，可行性，与临床密切相关However, the preventive effect of FA on cardiovascular disease remains unclear. Large-scale clinical trials failed to show a benefit from Hcy-lowering treatment in individuals with established cardiovascular disease or with history of myocardial infarction. However, those stud
3、ies evaluated high-dose FA supplementation as secondary prevention and were not investigating low-dose FA supplementation as primary prevention of cardiovascular disease .2.研究目的是否明确? 是，明确。The aim of this study was to analyze the association of low-dose folic acid supplementation with blood lipids co
4、ncentrations in subjects with atherosclerosis risk factors.3.设计方案是否作了优选? 研究对象是否明确?样本数量是否作了估算?类型：药物对照（自身前后对照），临床试验性研究样本选择：Initially, FA supplementation was offered to 147 subjects, 23 of whom (15.6%) were excluded in the course of the study due to non-compliance (irregular taking of FA, stopping it a
5、ltogether, or not reporting for the follow-up examination at the end of the treatment period).未做样本含量估算。The study enrolled 124 Caucasian individuals (60 M, ages 2039; and 64 F, ages 1939) with atherosclerosis risk factors (family history of premature ischemic stroke, arterial hypertension, dyslipidem
6、ia, overweight and obesity, cigarette smoking, and low level of physical activity). 样本选取合适4.诊断标准/纳入标准/排除标准是否明确?衡量指标是否恰当?所用名词定义明确，诊断指标，测量方法，结局指标清晰，可靠性高5.研究或试验流程是否明确?有无质量控制措施？共5个表，结果清晰，资料详尽，内部符合性高6.统计方法是否正确?采用统计方法合理，按男女分层分析，再按不同危险因素分析，控制和调整了混杂因素7.对该论文的总体感受如何？设计清晰，数据清晰，指标明确，有创新，贴近临床版面清晰In view of our r
7、esults, it seems that low-dose FA supplementation, used as primary prevention, has a beneficial effect on blood lipids through decreasing concentrations of total cholesterol and LDL and increasing concentrations of apoAI. To determine the value of FA in primary cardiovascular disease prevention, further studies are needed.为研究所证实，回答了研究问题
流行病学文献评价
