经肛内镜显微外科手术-TEM医学医药

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1、Treatment of rectal adenomas by transanal endoscopic microsurgery(TEM):15 yearsexperience,Surg Endosc.2009 姜海军,Background,present experience with rectal adenomas managed by transanal endoscopic microsurgery(TEM). Goal:evaluating morbidity, mortality, and local recurrence rate.,Patients and methods,E

2、nrolled:402 patients, preoperative diagnosis of adenomas.(1993.1-2008.10) Mean age:65 years(range22-92) Men:221 vs Women:181,distance of adenomas from the anal verge,0-3 cm: 28 patients 3-6 cm: 58 patients 6-12 cm: 251 patients 12-16 cm: 54 patients 16 cm: 11 patients,Lesion position,anterior wall o

3、f the rectum:92 patients posterior wall:107 patients lateral wall:88 patients semicircumferential:98 patients circumferential:17 patients,Preoperative therapy staging,digital examination to evaluate tumor fixation total colonoscopy rigid rectoscopy:macrobiopsies; measure the distance from the anal v

4、erge; determine the location and consequently select the position,transanal endosonography (EUS) by a rotative probe computed tomography (CT) scan or magnetic resonance imaging (MRI):giant and suspected lesions,Patient preparation,washout of the colon short-term antibiotic prophylaxis general anesth

5、esia in the majority of patients Spinal anesthesia was used in 65 (16.1%) high-risk patients(ASA 4).,1.supine position2.prone position 3.lateral position,place the lesion in the inferior part ofthe operative field,Fullthickness excision: 379 patients (94.3%) 1 cm minimum of normal mucosa around the

6、lesion Mucosectomy: 23 patients(5.7%),Mean operative time was 64 min (range = 22120). rectal defect was closed: endoluminal running suture with a silver clip placed at each end of the suture to avoid an intrarectal node.,only 15 patients (3.7%) required the repeated administration of ketorolac 30 mg

7、 in the first 48 h. drink liquids on the first postoperative day Mean hospital stay was 2.5 days (range = 18 days).,short-term results:,Minimal intraoperative complications: 13 cases an opening of the peritoneal cavity and in 1 patient there was an opening of the vagina All lesions were closed endos

8、copically by TEM without any intra- or postoperative consequences.,giant adenomas(2 cases):impossible to carry out a complete suture. temporary ileostomy closed after 2 months One of the two patients had a rectal stenosis required endoscopic dilatation. At follow-up of 24 and 30 months (the patient

9、with rectal stenosis) no other complications were observed.,Postoperative follow-up,mean follow-up :84 months (range = 1190 months) 1 month after discharge : clinical examination, digital rectal exploration, andrigid rectoscopy every 6 months for the first year and then annually (flexible endoscopy

10、with biopsies of the scar),complications,All leaking sutures resolved by local therapy (antibiotics and analgesic enema) and/or parenteral nutrition. Stool incontinence was treated with physiotherapy and anal sphincter biofeedback resolved within 2 months of the operation The patients with hemorrhag

11、ing, two of them with cirrhosis, required blood transfusions,Surgical drainage and colostomy (patient is alive after 1 year) Laparoscopic ileostomy and a new suture by TEM.(patient is alive after 2 years without other complications),Long-term results,No patients had a new recurrence at the next foll

12、ow-up Of the 34 patients with pT1 rectal cancer, the mean follow-up of 30 months (range = 1470 months) revealed no local recurrences or distant metastases.,Discussion,adenomas of the colon and rectum have the potential to become malignant; related to size, histological type (villous adenoma),and gra

13、de of dysplasia,Endoscopic polypectomy is not able to remove all large and sessile polyps due to technical problems in the middle or upper rectum,it may be difficult to excise it completely,Sometimes, large adenomas in the lower third of the rectum are treated by abdominoperineal excision or coloana

14、l anastomosis adenomas in the upper third of the rectum are removed by anterior resection Resection of the rectum is a major surgical procedure associated with significant morbidity (768%) and mortality (06.5%),TEM:minimally invasive and safe can reach further into the rectum than other forms of local excision(up to 20 cm from the anal verge),Risk:,pelvic abscess ,Infection bleeding perforation into the peritoneal cavity suture dehiscence stool incontinence (soiling) rectovaginal fistula,indication,Benign lesion: polyps adenomas Malignant lesion: T1N0 rectal tumor,Thank you,