Brain-Tumor-Systematic-Approach脑肿瘤MR诊断.ppt

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1、Brain Tumor - Systematic Approachby Robin Smithuis and Walter Montanera河南省人民医院放射科 高明 译讲,Introduction Incidence of CNS tumors Age distribution Tumor spread Intra- versus Extraaxial Midline crossing Multifocal disease Cortical based tumors CT and MR Characteristics,Fat - Calcification - Cyst High on T

2、1 Low on T2 Diffusion weighted imaging Perfusion Imaging Enhancement Differential diagnosisfor specific,anatomic area Skull base Sella/suprasellar Cerebello-pontine angle Pineal region Intraventricular 4th ventricle Tumor Mimics,Schwannoma located in the cerebellopontine angle (CPA)with typical sign

3、s of an extraaxial tumor,Meningioma with a broad dural base and a dural tail ， hyperostosis in the adjacent bone ， enhances homogeneously ， no blood-brain-barrier,Melanoma metastasis with gray matter on the anteromedial side of the lesion (red arrow) ， intra-axial.,Ependymoma with extension to the c

4、erebellopontine angle (blue arrow) and into the foramen magnum (red arrow) or to the cisterna magna,To assess the extent of a tumor. An extra-axial tumor in the region of the left cavernous sinus with homogeneous enhancement and a broad dural tail.This is typical for a meningioma.,Actual extent of t

5、his tumor is greater than expected. The tumor is situated in the pterygopalatine fossa and extends into the orbit. It also spreads anteriorly into the middle cranial fossa.,Consideration for the effect on the surrounding structures . Primary brain tumors are derived from brain cells and often have l

6、ess mass effect for their size than you would expect, due to their infiltrative growth . There is no enhancement so this would probably be a low-grade astrocytoma,The ability of tumors to cross the midlineGlioblastoma multiforme (GBM) frequently crosses the midline by infiltrating the white matter t

7、racts of the corpus callosum. Radiation necrosis can look like recurrent GBM and can sometimes cross the midline. Meningioma is an extra-axial tumor and can spread along the meninges to the contralateral side. Lymphoma is usually located near the midline. Epidermoid cysts can cross the midline via t

8、he subarachnoid space. MS can also present as a mass lesion in the corpus callosum.,Left: Metastases Right: Multiple meningiomas and a schwannoma in a patient with Neurofibromatosis II,Multifocal disease: Metastatic disease lymphomas Multicentric Glioblastoma multiforme (GBM) Gliomatosis cerebri See

9、ding metastases: Medulloblastomas ,Ependymomas, GBMs and oligodendrogliomas Phacomatoses: Neurofibromatosis I: optic gliomas and astrocytomas Neurofibromatosis II: meningiomas, ependymomas, choroid plexus papillomas Tuberous Sclerosis: subependymal tubers, intraventricular giant cell astrocytomas, e

10、pendymomas von Hippel Lindau: hemangioblastomasNon-tumorous diseases like small vessel disease, infections (septic emboli, abscesses) or demyelinating diseases like MS,Cortical based tumorsMost intra-axial tumors are located in the white matter.Some tumors, however, spread to or are located in the g

11、ray matter.These cortical based tumors includes oligodendroglioma, ganglioglioma and Dysembryoplastic Neuroepithial Tumor (DNET). The differential diagnosis includes non-tumorous lesions like cerebritis, herpes simplex encephalitis, infarction and post-ictal changes.,A 45-year-old female with a stab

12、le seizure disorder for 15 years.This is a ganglioglioma.The differential diagnosis includes DNET and pilocytic astrocytoma.,A 10-year-old male with secondary epilepsy . This is a Dysembryoplastic Neuroepithial Tumor (DNET).,52-year-old female who complained of headache and neck pain for one year wi

13、tha recent onset of tonic-clonic seizures . This is an infiltrating tumor which extends all the way to the cortex, with limited mass effect on surrounding structures and calcifications . The most likely diagnosis is oligodendroglioma .,Fat - Calcification - Cyst A ruptured dermoid cyst with the clas

14、sical findings.Chemical shift artefact indicates the presence of fat, seen only in the frequency encoding direction .Fat within a tumor is seen in lipomas, dermoid cysts and teratomas . Some tumors like lymphoma, colloid cyst and PNET-MB (medulloblastoma) can have a high density on CT.,A calcified m

15、ass in the suprasellar region, causing obstructive hydrocephalus.This location and the calcification are typical for a Craniopharyngioma.A pineocytoma itself does not calcify, but instead it explodes the calcifications of the pineal gland.,The calcification and the extension of the tumor to the cort

16、ex are very typical for an oligodendroglioma.An astrocytoma should be in the differential.,A patient with progressive visual loss. On the coronal and sagittal T1WI there is a large mass centered around the sella with a broad dural base. There is extension into the sella.This is a calcified meningiom

17、a.,Many cystic lesions can simulate a CNS tumor. These include epidermoid, dermoid, arachnoid, neuroenteric and neuroglial cysts, enlarged perivascular spaces of Virchow Robin.In order to determine whether a lesion is a cyst or cystic mass ，look for the following characteristics: Morphology Fluid/fl

18、uid level Content usually isointense to CSF on T1, T2 and FLAIR DWI: restricted diffusion An arachnoid cyst is isointense to CSF on all sequences. Tumor necrosis may sometimes look like a cyst, but it is never completely isointense to CSF.,Cystic versus Solid,On the left a craniopharyngioma with an

19、enhancing rim surrounding the cystic component.In the middle a neuroenteric cyst with the contents of which have the same signal intensity as CSF.On the right a glioblastoma multiforme (GBM) with a central cystic component.The enhancement in GBM is usually more irregular.,Most tumors have a low or i

20、ntermediate signal intensity on T1WI. Exceptions to this rule can indicate a specific type of tumor. Calcifications are mostly dark on T1WI, but depending on the matrix of the calcifications they can sometimes be bright on T1. Especially on gradient echo images slow flow can be seen as bright signal

21、 on T1WI and should not be confused with enhancement.If you only do an enhanced scan, remember that high signal is not always enhancement.,High on T1,Some tumors with high signal intensities on T1WI. On the far left images of a patient who presented with apoplexy. The high signal is due to hemorrhag

22、e in a pituitary macroadenoma. The patient in the middle has a glioblastoma multiforme, which caused a hemorrhage in the splenium of the corpus callosum. On the right is a patient with a metastasis of a melanoma. The high signal intensity is due to the melanin content.,Most tumors will be bright on

23、T2WI due to a high water content.When tumors have a low water content they are very dense and hypercellular and the cells have a high nuclear-cytoplasmasmic ratio.These tumors will be dark on T2WI. The classic examples are CNS lymphoma and PNET (also hyperdense on CT). Calcifications are mostly dark

24、 on T2WI.Paramagnetic effects cause a signal drop and are seen in tumors that contain hemosiderin. Proteinaceous material can be dark on T2 depending on the content of the protein itself. A classic example of this is the colloid cyst.Flow voids are also dark on T2 and indicate the presence of vessel

25、s or flow within a lesion. This is seen in tumors that contain a lot of vessels like hemangioblastomas, but also in non-tumorous lesions like vascular malformations.,Low on T2,Melanoma with melanin. GBM sometimes with a high nuclear-cytoplasmic ratio. Most GBMs are hyperintense on T2WI. PNET typical

26、ly has a high nuclear-cytoplasmic ratio，which mostly located in the region of the 4th ventricle, another less common location is in the region of the pineal gland. Mucinous metastases often with calcifications. Meningiomas ：iso-SI .High SI on T2WI if they contain a lot of water. Low SI on T2WI if th

27、ey are very dense and hypercellular or when they contain calcifications.,High intensity on DWI indicates restriction of the ability of water protons to diffuse extracellularly. Restricted diffusion is seen in abscesses, epidermoid cysts and acute infarction (due to cytotoxic edema). In cerebral absc

28、esses the diffusion is probably restricted due to the viscosity of pus, resulting in a high signal on DWI.In most tumors there is no restricted diffusion - even in necrotic or cystic components. This results in a normal, low signal on DWI.,Diffusion weighted imaging,Perfusion imaging can play an imp

29、ortant role in determining the malignancy grade of a CNS tumor. Perfusion depends on the vascularity of a tumor and is not dependent on the breakdown of the blood-brain barrier. The amount of perfusion shows a better correlation with the grade of malignancy of a tumor than the amount of contrast enh

30、ancement.,Perfusion Imaging,Blood brain barrierThe brain has a unique triple layered blood-brain barrier (BBB) with tight endothelial junctions in order to maintain a consistent internal milieu. Contrast will not leak into the brain unless this barrier is damaged. Enhancement is seen when a CNS tumo

31、r destroys the BBB. Extra-axial tumors such as meningiomas and schwannomas are not derived from brain cells and do not have a BBB. Therefore they will enhance. There is also no blood-brain barrier in the pituitary, pineal and choroid plexus regions. Some non-tumoral lesions enhance because they can

32、also break down the BBB and may simulate a brain tumor. These lesions include like infections, demyelinating diseases (MS) and infarctions.,Enhancement,Contrast enhancement cannot visualize the full extent of a tumor in cases of infiltrating tumors, like gliomas. The reason for this is that tumor ce

33、lls blend with the normal brain parenchyma where the blood brain barrier is still intact. Tumor cells can be found beyond the enhancing margins of the tumor and beyond any MR signal alteration - even beyond the area of edema.,On the T2WI there is a lesion in the left temporal lobe, found incidentall

34、y.There was no enhancement and the DWI was normal.During follow-up there was a slight increase in size.This was diagnosed as a low-grade astrocytoma.It is not possible to resect such a lesion, since the infiltrating tumors cells are within the normal-appearing brain tissue.,In gliomas - like astrocy

35、tomas, oligodendrogliomas and glioblastoma multiforme - enhancement usually indicates a higher degree of malignancy. Therefore when during the follow up of a low-grade glioma the tumor starts to enhance, it is a sign of malignant transformation.Gangliogliomas and pilocytic astrocytomas are the excep

36、tions to this rule: they are low-grade tumors, but they enhance vividly. As discussed above, it recently has been shown that tumor angiogenesis as shown by perfusion MR correlates better with tumor grade than enhancement after the administration of intravenous contrast.,Low-grade tumors with enhance

37、ment a Ganglioglioma (left) and a pilocytic astrocytoma (right),The amount of enhancement depends on the amount of contrast that is delivered to the interstitium.In general, the longer we wait, the better the interstitial enhancement will be. The optimal timing is about 30 minutes and it is better t

38、o give contrast at the start of the examination and to do the enhanced T1WI at the end.,Left: Schwannoma extending into the middle cranial fossa with homogeneous enhancemant Right: Primary lymphoma known for its vivid enhancement,No enhancement is seen in: Low grade astrocytomas Cystic non-tumoral l

39、esions: Dermoid cyst Epidermoid cyst Arachnoid cyst,An intra-axial tumor in an adult centered in the temporal lobe and involves the cortex.Massive infiltrative growth involving a large part of the right cerebral hemisphere, with minimal mass effect & no enhancement.These are typical for a low-grade

40、astrocytoma.,Homogeneous enhancement can be seen in: Metastases Lymphoma Germinoma and other pineal gland tumors Pituitary macroadenoma Pilocytic astrocytoma and hemangioblastoma (only the solid component) Ganglioglioma Meningioma and Schwannoma,Patchy enhancement can be seen in: Metastases Oligoden

41、droglioma Glioblastoma multiforme Radiation necrosis,A glioblastoma multiforme (GBM). The enhancement indicates that this is a high-grade tumor, but only parts of it enhance with a cystic component with ring enhancement.The tumor cells probably extend beyond the area of edema as seen on the FLAIR im

42、age, because gliomas grow infiltratively into normal brain - initially without any MR changes.,A large tumor is located in the right hemisphere with limited mass-effect , indicateing that there is marked infiltrative growth. Heterogeneity on both T2WI and FLAIR. There is patchy enhancement. All thes

43、e findings are typical for a GBM. Virtually no other tumor behaves in this way.,Three different ring enhancing lesions,Conspicuity of tumors with contrastThe case on the left demonstrates the value of Gadolinium in the conspicuity of tumors. This is a patient with Neurofibromatosis II. After the adm

44、inistration of contrast the two meningiomas and the schwannoma are easily seen.,Leptomeningeal metastases are usually not seen without the administration of intravenous contrast. The case on the top demonstrates the abnormal enhancement along the brainstem, along the folia of the cerebellum (yellow

45、arrow) and along the fifth intracranial nerve (blue arrow) in a patient with Leptomeningeal metastases.,Skull base Common skull base tumors either arise from extracranial structures like the sinuses (sinonasal carcinoma), or from the skull base itself (chordoma, chondrosarcoma, fibrous dysplasia).Ch

46、ordoma is usually located in the midline, while chondrasarcoma usually arises off the midline.,Differential diagnosisfor specific anatomic area,A midline tumor arising from the clivus.This is the typical presentation of a chordoma.The differential diagnosis would include a metastasis and a chondrosa

47、rcoma.,Another skull base tumor located off midline.This is a typical presentation for a chondrosarcoma.The differential diagnosis would include a metastasis and a paraganglioma.Chondrosarcomas can be located in the midline and chordomas are sometimes located off midline but those cases are exceptio

48、nal.,An example of a Skull Base Paraganglioma.,A 58-year-old male with a gradual onset of right facial pain and numbness and a recent onset of double vision.There is an enhancing mass anterior to the skull base and also in the region of the right cavernous sinus.In the bone window setting there is s

49、clerosis of the skull base, particularly in the region of the clivus.Continue with the MR images.,The most striking finding is the black clivus due to the sclerosis.A normal clivus is bright on T1WI as a result of the fatty bone marrow.There is an enhancing mass anterior to the clivus.On the coronal

50、 images we see the enhancement extending through the foramen ovale to the right of the cavernous sinus.The diagnosis is a Nasopharyngeal squamous cell carcinoma with intracranial extension.,Sella/suprasellar ：In this region it is important to keep the possibility of an Aneurysm in the differential d

51、iagnosis.,Images of a mass in the suprasellar cistern.On the NECT we can see that it contains calcium.On the T1WI there is a hyperintense area that shows no enhancement (i.e. cystic).There are other components that show enhancement.With a hydrocephalus.These findings are very specific for a Cranioph

52、aryngeoma.,On the left NECT and enhanced CT-images of a 33-year-old female with severe headache (worse in the a.m.), reduction in visual acuity and visual fields and papilledema.Continue with the MR images.,Notice the normal inferiorly displaced pituitary gland.This means it is not a macroadenoma.Th

53、e diagnosis is again a Craniopharyngioma.The differential diagnosis would include an astrocytoma and a meningioma.,Cerebello-pontine angle,A 52-year-old male with hearing loss on the right.The images show an unusual cystic mass with enhancing septations. There is also some enhancement within the int

54、ernal acoustic canal. Based on the images the most likely diagnosis would be a cystic schwannoma, but this happened to be an uncommon, cystic presentation of a Meningioma.,On the left a tumor located in the pineal region.Based on these images the differential diagnosis would include: Meningioma Pine

55、ocytoma Germ Cell Tumor This happened to be a meningioma.,On the left are typical images of a ruptured pineal region dermoid.,On the left images of a 40y/o female with blurred vision and memory decay for one month，graduall stoit ，nausea and vomiting . This is an Oligoastrocytoma Grade 3.,On the left

56、 images of a 12 y/o male with upward gaze paralysis. There is a tumor located in the pineal region.The tumor contains calcifications.There is homogeneous enhancement, which is common for a tumor in the pineal region (discussed above).Based on the age of the patient, the location and the tumor charac

57、teristics, this is most likely a Germinoma.,Intraventricular,On the left a tumor located in the 3rd ventricle.The tumor contains calcifications.The diagnosis is a Giant cell astrocytoma.,4th ventricle In children tumors in the 4th ventricle are very common.Astrocytomas are the most common followed b

58、y medulloblastomas (or PNET-MB), ependymomas and brainstem gliomas with a dorsal exophytic component. In adults tumors in the 4th ventricle are uncommon.Metastases are most frequently seen, followed by hemangioblastomas, choroid plexus papillomas and dermoid and epidermoid cysts.,Medulloblastoma,Man

59、y non-tumorous lesions can mimic a brain tumor.Abscesses can mimic metastases.Multiple sclerosis can present with a mass-like lesion with enhancement, also known as tumefactive multiple sclerosis.In the parasellar region one should always consider the possibility of a aneurysm.,Tumor Mimics,Infections and vascular lesions can also mimic a CNS tumor.,Thanks for your attention !,