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1、ADP : ; : ADP. PRPADP200mL・L-1 TYXN-91. 0.10.51.53.0mmol・L-1 ADP%26.33.333.42.473.43.194.92.7n=8P<0.05.ADPFI4.61.7FI10.32.6n=8P<0.01. ADP. Keywords:ferulic acid;ethyl ferulate;blood platelets;cal Abstract:AIM To investigate the inhibitory actions of ethyl ferulate on platelet con
2、gregate induced by ADPand the ef-fect of platelet intracellular calcium oscillations.METHODS To observe platelet congregate rate induced by congregater TYXN-91.200mL・L-1 polyethylene glycol400as contral.Platelet intracellular calcium oscillation were observed by laser scanning.RESULTS Ethyl f
3、erulate Inhibitions rate were%26.33.333.42.473.43.1and94.92.7n=8at different concentration0.10.51.5and3.0mmol・L-1 significantly increased than that of the group of ferulic acidthe change ofFI4.61.7is much lower than resting level10.32.6n=8P<0.01.CONCLUSION The inhibitive effect of Ethyl fe
4、rulate on platelet congregation induced by ADP was much more than that of ferulic acid. 0 12 .ADP. 1 1.1 ;Flu-o3-AM:;ADPSigma.TYXN-91;MRC-1024Bio-Rad.82.50.2kg. 1.2 1.2.1 ipPRPPPP.200mL・L-1 200mL・L-1 PPP.PRP0.45mL0.05mL373minADP12moL・L-1 .:=- 100% 1.2.2 Ca2+ 1.5cm.PRP200L3000r&#
5、12539;min-1 10min10moL・L-1 Flu-o3-AM200L374050min3000r・min-1 10minHEPES200L100L1mmoL・L-1 Ca2+ HEPES50L1mmoL・L-1 200mL・L-1 400373min12mol・L-1 ADP. :SPSSt. 2 2.1 ADP 1mmoL・L-1 ADPFig1.76.4%57.2%.ADP.0.10.51.53.0mmoL・L-1 26.33.333.42.473.43.194.92
6、.714.71.321.72.159.62.782.33.2n=8P<0.05Fig2. 2.2 ADP.ADP FI10.32.6Fig3.ADPFI4.61.7n=8P<0.05Fig4. 1 2 3 .3 4 .5 .ADP. 3 4 .CIPCa2+ .6 .ADPCa2+ Ca2+ .CCa2+ . : 1Zhou JYFan YHan ZFWu DZHu ZB.Influence of ferulic acid sodium on the enhance of endothelial permeability induced by histamine J.Zhonggu
7、o Yaolixue TongbaoChin Pharm Bull J2000;166:664-666. 2Yu HHong JLWu DF.Effect of sodium ferulate on prolifera-tion of rabit aortico smooth muscle cells induced by oxidized LDL J.Zhongguo Zhongyao ZazhiChin J Chin Materia Mdeica1999;246:365-367. 3Li YPeng Y.Protective effects of sodium ferulate and e
8、thanol sediments from danggui on immunological liver injury J.Zhongcao YaoChin Traditional Herbal Drugs J2000;314:274-276. 4Tang GHJiang GHWang SZZheng LF.Studies on synthesis and pharmacological activity of ferulic acid salts J.Zhongguo Yaoxue ZazhiChin Pharm J1999;3410:697-699. 5Li TXYuan CYYang J
9、WSan CW.Synthesis of the Poly-meric Cruga Derivative of Ferulic Acid and Its Effect on Platelet Aggregation and Release of TXB2and6-Keto-PGF1 J.Zhongguo Yaowu Huaxue ZazhiChin J Med Chem1999;92:98-101. 6Cong YLJin CLi XFLi NLu GQ.Oral L-arginine in re-ducing the peak value of platelet intracellular calcium oscillation induce by ADP J.Zhonghua Jianyan Yixue ZazhiChin J Lab Med J2000;231:32-34.
阿魏酸乙酯抗ADP诱导的血小板聚集及其机制
