赢创德固赛在农药剂型SCODEW研发新进展

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1、赢创德固赛在农药剂型SCODEW研发新进展赢创德固赛在农药剂型赢创德固赛在农药剂型SC,OD,EW研发新进展研发新进展SC,OD,EW formulation developmentEvonik Degussa,Shanghai袁永新 胡圣豪赢创德固赛在农药剂型SCODEW研发新进展2 solid formulation solid formulation 固体制固体制剂剂SG，WP，SP，WDG liquid formulation liquid formulation 液体液体制剂制剂SL，ME，EC，EW，SC，CS Formulation type and treand 制剂类型及发展

2、方向农药剂型发展方向农药剂型发展方向水性化水性化粒状化粒状化多功能多功能缓释缓释省力省力精细化精细化赢创德固赛在农药剂型SCODEW研发新进展3Ratio of formulation in china Ratio of formulation in china 国内剂型比例制剂类型及发展方向国内剂型比例制剂类型及发展方向ECEC乳油乳油26%26%WPWP可湿性粉剂可湿性粉剂 10%10%SCSC悬浮剂悬浮剂16%16%SL SL 水剂水剂19%19%WDGWDG水分散粒剂水分散粒剂 12%12%OthersOthers其其它它12%12%EW EW 水乳剂水乳剂5%5%赢创德固赛在农药剂型

3、SCODEW研发新进展4Suspension concentration (Suspension concentration (水悬浮剂）水悬浮剂）SC TG is milled finely and suspended in the water SC TG is milled finely and suspended in the water with dispersing agent,wetting agent,with dispersing agent,wetting agent,thickner,adjuvant thickner,adjuvant 是将固体原药磨细以后，悬浮于含有分散

4、剂，润湿剂，增稠剂，是将固体原药磨细以后，悬浮于含有分散剂，润湿剂，增稠剂，增效剂的水中。增效剂的水中。Advantages:Advantages:No solvent 没有溶剂。Can contain high concentrations of ai 高含量。Easy to measure and mix 容易称量混合。Compatible with aqueous concentrates 与水剂型制剂兼容。Disadvantages:Disadvantages:Difficult to produce successfully 研发难度大。Can settle out in stora

5、ge 贮存中沉淀。Sensitive to freezing 不耐冻。Sensitive to ai purity and polymorphic form 对原药杂质和晶体免感。赢创德固赛在农药剂型SCODEW研发新进展5Suspension concentration 水悬浮剂水悬浮剂ComponentTypical Amount%w/wActive Ingredient（原药）80Wetter（润湿剂)1-2Dispersant(分散剂）3-6Antifoam（消泡剂）0.5Antifreeze（防冻剂）5-20Antisettling agent（抗沉降剂）0.1 2Biocide（防

6、腐剂）0-0.2Water（水）To volume赢创德固赛在农药剂型SCODEW研发新进展6Dispersants Dispersants 分散剂分散剂Dispersants can give steric and electrostatic stabilization of fine solid particles in water分散剂可以通过空间位阻或者静电作用将细小颗粒悬浮在水中。Dispersants can stop the process of aggregation and crystallation 分散剂可以防止粒子的聚合和重结晶（奥式熟化）Dispersants can

7、 reduce the milling viscosity 分散剂可以降低研磨粘度赢创德固赛在农药剂型SCODEW研发新进展Page|7Techincal problem in SC development Techincal problem in SC development SCSC研发中的技术难题研发中的技术难题Viscosity increase in milling Viscosity increase in milling 研磨时粘度增大研磨时粘度增大 SolutionAdd more dispersants增加更多 的 分散剂 Change dispersants改变分散剂 Us

8、e the combination of different sorts of dispersants使用不同种类的分散剂组合 赢创德固赛在农药剂型SCODEW研发新进展8Techincal problem in SC development SC研发中的技术难题研发中的技术难题Foam in milling Foam in milling 研磨中泡沫多研磨中泡沫多 Solution 解决方案Change antifoam 改变消泡剂 change wetter 改变润湿剂 Reduce the wetter减少润湿剂Change dispersants 改变分散剂赢创德固赛在农药剂型SCOD

9、EW研发新进展9Technical problem in SC development SC研发中的技术难题研发中的技术难题Particle increase in storage 粒径在贮存中增加粒径在贮存中增加Aggrecation of particle 粒径絮凝粒径絮凝 Solution 解决方案Change the dispersants 改变分散剂Add more dispersants增加分散剂用量Use combination of dispersants使用分散剂组合 Add some structure agent加些结构剂赢创德固赛在农药剂型SCODEW研发新进展10Fu

10、ngicide Fungicide alonealone单用杀菌剂单用杀菌剂Pesticide droplet on surface of leaf喷雾液呈喷雾液呈水珠状，不能水珠状，不能润湿菌丝润湿菌丝Techincal problem in SC development SC研发中的技术难题研发中的技术难题Particle increase in storage 在贮存中粒径增大在贮存中粒径增大Crystallation of particle 粒径的重结晶粒径的重结晶Solution 解决方案Use combination of dsiperants使用分散剂组合Use dispersa

11、nts with high CMC使用具有高CMC 的分散剂Use comb polymeric surfactant 使用 梳妆聚合物分散剂Add some inogranic salt 加一些无机盐Add some water soluble polymer with high moleculer weight 加 水溶性高分子量高聚物赢创德固赛在农药剂型SCODEW研发新进展11 Imidacloprid SC 600formulationImidacloprid SC 600formulation吡虫啉产品介绍吡虫啉产品介绍 具有时代特质的划时代杀虫剂具有时代特质的划时代杀虫剂-吡虫啉

12、吡虫啉1.结构独特，高效，低毒，低残留的特异性烟碱类杀虫剂2.杀虫镨广，适用作物多，用量少，持久期长，应用安全，环境友好。3.作用机理；胃毒，触杀，内吸应用现状及前景仍将是主要应用的杀虫剂合理的剂型选择很重要 水悬浮剂 水分散粒剂赢创德固赛在农药剂型SCODEW研发新进展Page|12 Imidacloprid SC 600formulationImidacloprid SC 600formulation吡虫啉吡虫啉600g/L 600g/L 配方组成配方组成Guideline Guideline FormulationFormulationImidacloprid Imidacloprid

13、WaterPGBREAK-THRU DA BREAK-THRU DA 646646BREAK-THRU DA BREAK-THRU DA 675675ThickenerBiocide600g/L 吡虫啉 SC600吡虫啉研磨相入水效果赢创德固赛在农药剂型SCODEW研发新进展Page|13SC Stability Test Using LumifugeSC Stability Test Using Lumifuge悬浮剂稳定性的评测方法悬浮剂稳定性的评测方法Unstable Unstable Stable with Stable with BREAK-THRUBREAK-THRU赢创德固赛在农

14、药剂型SCODEW研发新进展14 Imidacloprid SC 600formulation吡虫啉吡虫啉600g/L配方评价配方评价ItemItem项目项目Suspensibility Suspensibility 悬浮率悬浮率Particle Particle size size 粒径粒径(D50)(D50)Viscosity Viscosity 粘度粘度 Separation and Separation and sediment sediment 分层分层 和沉淀和沉淀RT 98%5.8450no separation no sedimentation（不析水 不沉降）HT98%6.0

15、380Little separation No sedimentation（少量析水，没有沉淀）Analysis the formulation by storage in 54C for 28days热贮28天54C下的情况赢创德固赛在农药剂型SCODEW研发新进展Page|15Particle size analysis Imidacloprid SC 600formulation吡虫啉吡虫啉600g/L赢创德固赛在农药剂型SCODEW研发新进展Page|16Particle size analysis Imidacloprid SC 600formulation吡虫啉吡虫啉600g/L赢

16、创德固赛在农药剂型SCODEW研发新进展20%Pyridaben SC20%Pyridaben SC formulation formulation20%20%哒螨灵哒螨灵 配方组成配方组成Guideline FormulationGuideline FormulationPyridaben PGBREAK-THRU DA 646BREAK-THRU DA 646BREAK-THRU DA 655BREAK-THRU DA 655ThickenerBiocideWater赢创德固赛在农药剂型SCODEW研发新进展18BREAK-THRUBREAK-THRU Product DA Series

17、for In-Can Product DA Series for In-Can Formulations/Formulations/赢创德固赛公司赢创德固赛公司SCSC配方助剂产配方助剂产品品-BreakThru DA 646-BreakThru DA 655-BreakThru DA 675-BreakThru DA 752 W-BreakThru AF 9903-Tego Antifoam 32 H 赢创德固赛在农药剂型SCODEW研发新进展Page|19BREAK-THRUBREAK-THRU Product DA Series for In-Can Product DA Series

18、for In-Can Formulations/Formulations/赢创德固赛公司赢创德固赛公司SCSC配方助剂产配方助剂产品品BreakThru DA 646Special poly ether（特殊的聚醚分散剂）（特殊的聚醚分散剂）Reducing of milling time（减少研磨时间）Preventing Ostwald ripening and agglomeration（防止奥式熟化和粒子聚集）Acting as wetting agent（具有润湿作用）赢创德固赛在农药剂型SCODEW研发新进展Page|20BREAK-THRUBREAK-THRU Product D

19、A Series for In-Can Product DA Series for In-Can Formulations/Formulations/赢创德固赛公司赢创德固赛公司SCSC配方助剂产配方助剂产品品BreakThru DA 655Special Polyetherphosphate（特殊的聚醚磷酸酯）Can use in OD,SC,EW.（可以在OD，SC，EW中使用）BreakThru DA 675a polymer dispersants（共聚物分散剂）-Extremely efficient dispersant which yields high loading SC a

20、nd lower pre-mill viscosities（高效分散剂，可以制备高含量，降低研磨粘度）-Better stability-irreversibly adsorbs onto toxicant surface（很好吸附作用，增加制剂稳定性）-Must be used in conjunction with a wetter（必须和润湿剂联用）赢创德固赛在农药剂型SCODEW研发新进展Page|21BREAK-THRUBREAK-THRU Product DA Series for In-Can Product DA Series for In-Can Formulations/F

21、ormulations/赢创德固赛公司赢创德固赛公司SCSC配方助剂产配方助剂产品品BREAK-THRU AF 9903TEGO ANTIFOAM 32 H极好的水基消泡剂。极好的水基消泡剂。烷基糖苷烷基糖苷加32H赢创德固赛在农药剂型SCODEW研发新进展Page|22赢创德固赛成功开发的赢创德固赛成功开发的SCSC产品名录产品名录600克克/升升 吡虫啉吡虫啉 SC 350克克/升升 吡虫啉吡虫啉 SC200克克/升升 吡虫啉吡虫啉 SC50%百菌清百菌清 SC430g/Lg/L 戊唑醇戊唑醇 SC500g/L 500g/L 多菌灵多菌灵 SCSC250g/L 250g/L 硫磺硫磺 SC

22、SC20%20%哒螨灵哒螨灵 SC SC 500g/L 500g/L 丁醚脲丁醚脲SCSC200g/L 200g/L 氟虫腈氟虫腈SCSC2,4D/毒草定毒草定 SC代森锰锌代森锰锌 SC甲氧基丙烯酸酯甲氧基丙烯酸酯 SC硼硼 SC赢创德固赛在农药剂型SCODEW研发新进展Emulsion in WaterEmulsion in Water水乳剂水乳剂EW TG is high sheared finely and suspended in EW TG is high sheared finely and suspended in the water with dispersing agent

23、,thicknerthe water with dispersing agent,thickner是将液体剪切剪细以后，悬浮于含有分散剂，增稠剂的是将液体剪切剪细以后，悬浮于含有分散剂，增稠剂的水中水中AdvantagesAdvantages（优点）（优点）:Minimal skin and eye irritation（极低的皮肤和眼睛刺激）Less or no solvent（很少或者没有溶剂）Minimal toxicity（低毒）Low or no flammability（极低起燃性）DisadvantagesDisadvantages（缺点）（缺点）:May be temperat

24、ure sensitive（对温度敏感）赢创德固赛在农药剂型SCODEW研发新进展24EWEW 水乳剂水乳剂ComponentTypical Amount%w/wActive Ingredient（原药）50Solvent（溶剂)0-20Dispersant(分散剂）1.5-10Antifoam（消泡剂）0.5Antifreeze（防冻剂）5-20Antisettling agent（抗沉降剂）0 2Biocide（防腐剂）0-0.2Water（水）To volume赢创德固赛在农药剂型SCODEW研发新进展25Technic in EW formulationTechnic in EW fo

25、rmulationEW EW 的技术关键的技术关键Good combination of high HLB Surfactant and low HLB surfactant Good combination of high HLB Surfactant and low HLB surfactant 合理使用高合理使用高HLBHLB值和低值和低HLBHLB值的分散剂组合值的分散剂组合Select good thicknerSelect good thickner合理选用增稠剂合理选用增稠剂Select suitable solventSelect suitable solvent合理选用溶剂合

26、理选用溶剂赢创德固赛在农药剂型SCODEW研发新进展26Chlorpyrifos 40Chlorpyrifos 40 Evoniks EW formulationEvoniks EW formulation毒死蜱毒死蜱40%40%EWEW Chlorpyrifos 40%Solvesso 200BREAK-THRU DA 655BREAK-THRU DA 655BREAK-THRU DA 646BREAK-THRU DA 646PGAF 9903thicknerWater赢创德固赛在农药剂型SCODEW研发新进展Page|27BREAK-THRUBREAK-THRU Product DA Se

27、ries for In-Can Product DA Series for In-Can Formulations/Formulations/赢创德固赛公司赢创德固赛公司EWEW配方助剂配方助剂-BreakThru DA 646-BreakThru DA 655-BreakThru DA 675-BreakThru AF9903-Tego antifoam 32H BreakThru DA 646和和BreakThru DA 655搭配使用于各种水乳搭配使用于各种水乳剂配方中。剂配方中。赢创德固赛在农药剂型SCODEW研发新进展Page|28赢创德固赛成功开发产品名录赢创德固赛成功开发产品名录

28、400克克/升升 毒死蜱毒死蜱 EW500克克/升升 丙草胺丙草胺 EW5.7%5.7%氟氯氰菊酯氟氯氰菊酯 EWEW5.0%5.0%高效氯氟氰菊酯高效氯氟氰菊酯 EWEW 5.0%5.0%阿维菌素阿维菌素 EWEW100100克克/升升 氯氰菊酯氯氰菊酯 EW2525克克/升升 溴氰菊酯溴氰菊酯 EW赢创德固赛在农药剂型SCODEW研发新进展Page|29 OD ODT TG is milled finely and suspended in oil with G is milled finely and suspended in oil with dispersing agent,emul

29、sifier,antisettling agent.dispersing agent,emulsifier,antisettling agent.是将固体原药磨细以后，悬浮于含有分散剂，乳化剂，是将固体原药磨细以后，悬浮于含有分散剂，乳化剂，增稠剂的油中。增稠剂的油中。ComponentTypical Amount%w/w0Active Ingredient（原药）50Emulsifier（乳化剂)10-15Dispersant(分散剂）2-6Antifoam（消泡剂）0.5Antisettling agent（抗沉降剂）0.1 4Anti oxide（抗氧化剂剂）0-1Oil（油）To vo

30、lume赢创德固赛在农药剂型SCODEW研发新进展30Dispersants and emulsifier may interfere each other,a Dispersants and emulsifier may interfere each other,a good combination is very important for ODgood combination is very important for OD分散剂和乳化剂可能互相影响，因此需要好的分散剂，乳化剂组合。分散剂和乳化剂可能互相影响，因此需要好的分散剂，乳化剂组合。Change the HLB to get a

31、 good emulsion Change the HLB to get a good emulsion 调节调节HLBHLB以达到好乳化效果以达到好乳化效果Use suitable antisettling agent Use suitable antisettling agent to get suitable to get suitable formulation formulation 选择合适的增稠剂选择合适的增稠剂Techincal in OD formulation Techincal in OD formulation 油悬浮剂技术油悬浮剂技术赢创德固赛在农药剂型SCODEW研

32、发新进展Page|31Sulfonylurea OD Formulation with BREAK-THRUSulfonylurea OD Formulation with BREAK-THRU OE OE 441441油悬浮剂油悬浮剂ODOD：磺酰脲类油悬浮剂添加博力通：磺酰脲类油悬浮剂添加博力通 OE441 OE441 磺酰脲类农药水解稳定性低，大多以磺酰脲类农药水解稳定性低，大多以WDGWDG剂型为主剂型为主 Sulfonylurea is Sulfonylurea is typically formulated as WDG due to hydrolysistypically for

33、mulated as WDG due to hydrolysis 使用时常用桶混助剂提高渗透内吸能力使用时常用桶混助剂提高渗透内吸能力 Tank mix adjuvants added to Tank mix adjuvants added to improve uptake of a.i.(active ingredient)improve uptake of a.i.(active ingredient)液体制剂使用方便，但面临的难题包括：液体制剂使用方便，但面临的难题包括：Liquid formulations are more Liquid formulations are more

34、convenient,but challengingconvenient,but challenging 合适的乳化剂合适的乳化剂EmulsifierEmulsifier 合适的分散剂合适的分散剂DispersantDispersant 合适的润湿剂合适的润湿剂Wetting agentWetting agent 制剂的分散稳定性制剂的分散稳定性Physical Stability of DispersionPhysical Stability of Dispersion 化学稳定不水解化学稳定不水解Chemical stability of Sulfonylurea Chemical sta

35、bility of Sulfonylurea 防治药效防治药效Biological performanceBiological performance赢创德固赛在农药剂型SCODEW研发新进展32Example of an OD formulation based on BREAK-THRUExample of an OD formulation based on BREAK-THRU ProductsProducts以博力通助剂开发的油悬浮剂烟嘧磺隆以博力通助剂开发的油悬浮剂烟嘧磺隆4 4 OD OD Guideline Nicosulfuron(40g/l)Guideline Nicosu

36、lfuron(40g/l)OD Formulation:OD Formulation:烟嘧磺隆烟嘧磺隆(40g/l)OD(40g/l)OD 配方配方 MaterialMaterial wt.%wt.%Active Active 4.54.5Soybean OilSoybean Oil 68.568.5（BREAK-THRUBREAK-THRU OE 441 OE 441）5 5 BREAK-THRUBREAK-THRU DA 652 DA 652 2.82.8BREAK-THRUBREAK-THRU V 20 V 20 12.212.2Thickener Thickener 3 3相差显微镜P

37、hase contrast microscope放大比例10倍，10 times magnified德固赛油悬浮剂的物理状态德固赛油悬浮剂的物理状态:细小，均一的颗粒细小，均一的颗粒 通过加速贮存检验通过加速贮存检验 54 C:54 C:粘度粘度=28 mPas 25 C=28 mPas 25 C赢创德固赛在农药剂型SCODEW研发新进展33Formulation Stability by HPLC AnalysisFormulation Stability by HPLC Analysis配方稳定性通过了配方稳定性通过了HPLCHPLC检验检验 化学降解检测对烟嘧磺隆很重要，我们的配方通过了

38、稳定性的检测。Standard 6NicosulforonRF Mode:Standards 050010001500Area0.00000.00010.00020.00030.00040.00050.00060.00070.0008AmountCalibration 1-40 g/mlNicosulfuron(SC)A(8,1)HPLC,HPLC_5.071108_1448_Nicosulforon,8,1,1Acquired Freitag,9.November 2007 11:47:39050010001500Response02468101214Retention time5.28 N

39、icosulforon赢创德固赛在农药剂型SCODEW研发新进展34Greenhouse Results for Nicosulfuron Formulations Greenhouse Results for Nicosulfuron Formulations(10 g a.i./ha)with Meadow Grass(Poa pratensis)(10 g a.i./ha)with Meadow Grass(Poa pratensis)温室验证对草地早熟禾的药效温室验证对草地早熟禾的药效药效(%)我们产品跟市场标杆产品的药效比较我们产品跟市场标杆产品的药效比较赢创德固赛在农药剂型SCOD

40、EW研发新进展Page|35BREAK-THRUBREAK-THRU Product DA Series for In-Can Product DA Series for In-Can Formulations/Formulations/博力通配方博力通配方DADA系列产品系列产品-BreakThru DA 652-BreakThru DA 655-BreakThru DA 700-BreakThru EM V 20-BreakThru AF 9902-BreakThru OE 441 赢创德固赛在农药剂型SCODEW研发新进展Page|36BREAK-THRUBREAK-THRU Produ

41、ct DA Series for In-Can Product DA Series for In-Can Formulations/Formulations/博力通配方博力通配方DADA系列产品系列产品Break Thru DA 652是脂肪醇衍生物是脂肪醇衍生物 很好的油悬浮剂分散剂，可以极大地降低油悬浮剂的粘度，控制油悬浮很好的油悬浮剂分散剂，可以极大地降低油悬浮剂的粘度，控制油悬浮剂的析油，控制粒径的增长。剂的析油，控制粒径的增长。Break Thru EM V20 Vegetable-based nonionic emulsifierVegetable-based nonionic e

42、mulsifier 植物源非离子型乳化剂植物源非离子型乳化剂 Excellent ecological,toxicological and dermatological behavior Excellent ecological,toxicological and dermatological behavior 低毒、环境安全低毒、环境安全 Exceptional emulsifying properties for vegetable oils e.g.seed Exceptional emulsifying properties for vegetable oils e.g.seed oi

43、lsoils 对植物油乳化性能特别优异对植物油乳化性能特别优异赢创德固赛在农药剂型SCODEW研发新进展Page|37赢创德固赛成功开发产品名录赢创德固赛成功开发产品名录烟嘧磺隆烟嘧磺隆 40克克/升升 OD烟嘧磺隆烟嘧磺隆 +莠去津莠去津23%OD赢创德固赛在农药剂型SCODEW研发新进展Designed specific adjuvant Designed specific adjuvant actionsactions特效增效剂特效增效剂ActionS240S233VibrantOE 441OE 444 G 850Anti-Foam-+-Anti-Drift-/0-/0+/+0/+0/+

44、-/0Anti-Evaporant-00+Anti-Bouncing+Adhesion/Dep.+/+Rainfastness+0/-+Penetration time+0(sl)0(sl)+Wetting/Spreading+00+Stomata Flooding+00+Wax solubilization000000Membrane penetr.+0+Uptake/transport+(sl)+(sl)+赢创德固赛在农药剂型SCODEW研发新进展欢迎光临德固赛公司亚太农化技欢迎光临德固赛公司亚太农化技术中心术中心赢创德固赛（中国）投资有限公司赢创德固赛（中国）投资有限公司 仪器设备专属装

45、置：仪器设备专属装置：砂磨机砂磨机剪切机剪切机高速分散机高速分散机Lumifuge Lumifuge 稳定分析仪稳定分析仪高级显微镜高级显微镜粘度计粘度计表面张力仪表面张力仪共享装置：共享装置：粒径分布仪粒径分布仪赢创德固赛在农药剂型SCODEW研发新进展第九届全国农药研讨会上海第九届全国农药研讨会上海1010月月2121日下午，华夏宾馆华夏厅日下午，华夏宾馆华夏厅9:00-9:10嘉宾致词赢创德固赛特殊工业品 亚太市场销售总裁Christian Bierhaus9:10-10:10赢创德固赛农用配方助剂的国外应用技术Craig Poffenberger 博士/张宇辉10:10-10:50新型

46、农用桶混助剂在农业上的应用胡圣豪10:50-11:20液体农药剂型开发新进展袁永新工程师11:20-11:50草甘膦制剂和水剂农药的产品开发胡圣豪11：50致谢大中国区经理 张宇辉高效、环保新颖农药助剂研讨会高效、环保新颖农药助剂研讨会Seminar of agro adjuvant from EvonikSeminar of agro adjuvant from Evonik赢创德固赛在农药剂型SCODEW研发新进展41 Evonik Adjuvants赢创德固赛（中国）投资有限公司赢创德固赛（中国）投资有限公司 电话：电话：021021，传真：传真：0210216119140661191406EmailEmail：oriba.oriba.网站：网站：www.break-www.break-赢创德固赛在农药剂型SCODEW研发新进展